Drugs with Medicare negotiated prices in 2027
| Drug | Commonly used for | Negotiated price since |
|---|---|---|
| Ozempic, Rybelsus, Wegovy | type 2 diabetes; Wegovy also heart risk with obesity | 2027 |
| Trelegy Ellipta, Breo Ellipta | COPD, asthma | 2027 |
| Otezla, Otezla XR | psoriasis, psoriatic arthritis | 2027 |
| Janumet, Janumet XR; Tradjenta | type 2 diabetes | 2027 |
| Xtandi, Ibrance, Calquence, Pomalyst | prostate cancer, breast cancer, blood cancers | 2027 |
| Ofev | pulmonary fibrosis | 2027 |
| Linzess, Xifaxan | constipation and IBS; hepatic encephalopathy | 2027 |
| Austedo, Austedo XR; Vraylar | movement disorders; schizophrenia, bipolar disorder | 2027 |
| Eliquis | atrial fibrillation, blood clots | 2026 |
| Jardiance, Farxiga | type 2 diabetes, heart failure, kidney disease | 2026 |
| Januvia | type 2 diabetes | 2026 |
| Enbrel | rheumatoid arthritis, psoriasis | 2026 |
| Imbruvica | blood cancers | 2026 |
CMS posts each negotiated price and an explanation on its "Selected drugs and negotiated prices" page. Dollar prices aren't repeated here because what you pay is set by your plan.
Drugs that lose their negotiated price on January 1, 2027
A drug leaves the program once a generic or biosimilar is approved and marketed. CMS made that determination for four first-round drugs, so their negotiated prices end December 31, 2026:
- Stelara (biosimilars marketed)
- Xarelto (generic marketed)
- Entresto (generic marketed)
- NovoLog and Fiasp insulins (the $35 monthly insulin cap still applies)
If you take one of these, read your plan's 2027 Annual Notice of Change to see how it covers the brand and any generic or biosimilar.
What it means for you in North Carolina
- Check the formulary, not the price list. A negotiated price doesn't guarantee that any of North Carolina's 11 standalone Part D plans, or your Medicare Advantage plan, covers the drug. Look up your drugs on PlanMatch or Medicare.gov's Plan Finder.
- Remember the yearly cap. Whatever the price, your 2027 out-of-pocket spending on covered Part D drugs stops at $2,400. See the 2027 cap.
- Weight loss is still excluded. Semaglutide's negotiated price doesn't let Part D plans cover it for weight loss alone; the separate Medicare GLP-1 Bridge covers Wegovy for eligible people through 2027.
- Compare before December 7, 2026. You can request a call from a licensed insurance agent, who can compare plans from the companies they work with.
See all 24 drug pages at Medicare drug coverage in North Carolina.
Related questions
What is the Part D out-of-pocket cap for 2027?
The most you pay for covered drugs.
How many Part D plans are in North Carolina for 2027?
The state's 2027 plan count.
Is there still a Medicare donut hole?
How Part D changed in 2025.
Sources
- CMS — Selected drugs and negotiated prices (2026 and 2027 lists, drugs with deselection determinations; updated November 2, 2026)
- CMS — Negotiated prices for initial price applicability year 2027 (fact sheet)
- CMS — Selected drugs and renegotiation for initial price applicability year 2028 (January 2026)
- CMS — Medicare GLP-1 Bridge
- CMS — Medicare Advantage and Part D Landscape files, 2027 (PDP Region 08: North Carolina)
More questions in this guide
- Does North Carolina have a prescription assistance program for seniors?
- How many Part D plans are available in North Carolina for 2027?
- Is there still a donut hole in Medicare Part D?
- What is the Medicare Prescription Payment Plan?
- What is the Medicare Part D out-of-pocket cap for 2027?
Part of the guide: Medicare Part D in North Carolina · All questions
Frequently asked questions
Does a negotiated price mean my copay goes down?
Not necessarily. The negotiated price (the maximum fair price) is what Part D plans and pharmacies pay. Your copay or coinsurance is set by your plan, so check its 2027 formulary.
Do negotiated prices apply at every North Carolina pharmacy?
The negotiated price applies when a Part D plan covers the drug for someone with Medicare. Your plan's pharmacy network still affects what you pay, so use an in-network pharmacy.
Which drugs are next?
In January 2026 CMS selected 15 drugs for prices starting in 2028, including Trulicity and, for the first time, drugs covered under Part B, and chose Tradjenta for renegotiation.
Medicare in your North Carolina county
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